我父亲肺鳞癌的治疗贴(2014年3月1日驾鹤西去）

英雄武松 · 发表于 2012-1-10 01:48:24

文章很好，可惜读不了。

老马 · 发表于 2012-1-10 08:04:36

EGFR抑制剂（EGFR TKIs）无论是小分子药物还是单克隆抗体，均具有良好的安全性和耐受性，常见不良反应有皮肤毒性和腹泻，罕见不良反应有间质性肺炎、肝功能异常、口腔炎、脱发、口腔干燥等，无威胁患者生命的血液学毒性。与化疗毒副反应的处理措施不同，应用此类药物出现不良反应并非停药的指征，反而是肿瘤对靶向药物敏感的临床信号。许多研究发现皮疹与EGFR TKIs治疗的疗效相关，中重度皮疹患者总体生存明显优于轻度或无皮疹的患者。

老马 · 发表于 2012-1-10 19:19:37

本帖最后由老马于 2012-1-11 13:26 编辑

EGFR基因突变和高表达与疗效的关系

老马 · 发表于 2012-1-11 13:32:16

本帖最后由老马于 2012-1-11 13:38 编辑

阿瓦斯丁联用特罗凯
http://cancergrace.org/lung/2010 ... s-overall-survival/

老马 · 发表于 2012-1-13 18:29:37

本帖最后由老马于 2012-1-15 14:52 编辑

最近老爸胃口不错，经常有练练书法，但还是懒得锻炼身体。
今天买了美国雅培安素Ensure成人复合蛋白质营养粉397g，和润肤霜。

肠内营养制剂主要成分一览表.rar (6.25 KB, 下载次数: 560)

老马 · 发表于 2012-1-13 18:46:44

本帖最后由老马于 2012-1-13 21:20 编辑

爱必妥和阿瓦斯丁的比较

http://cancergrace.org/lung/2008/08/30/bms099-os-neg/

http://cancergrace.org/lung/2007/12/27/platgem-erbitux-trial/
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Overall survival with cisplatin–gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)
Patients and methods: Patients (n = 1043) received cisplatin 80 mg/m2 and gemcitabine 1250 mg/m2 for up to six cycles plus bevacizumab 7.5 mg/kg (n = 345), bevacizumab 15 mg/kg (n = 351) or placebo (n = 347) every 3 weeks until progression. Primary end point was progression-free survival (PFS); OS was a secondary end point.
Results: Significant PFS prolongation with bevacizumab compared with placebo was maintained with longer follow-up {hazard ratio (HR) [95% confidence interval (CI)] 0.75 (0.64–0.87), P = 0.0003 and 0.85 (0.73–1.00), P = 0.0456} for the 7.5 and 15 mg/kg groups, respectively. Median OS was >13 months in all treatment groups; nevertheless, OS was not significantly increased with bevacizumab [HR (95% CI) 0.93 (0.78–1.11), P = 0.420 and 1.03 (0.86–1.23), P = 0.761] for the 7.5 and 15 mg/kg groups, respectively, versus placebo. Most patients (～62%) received multiple lines of poststudy treatment. Updated safety results are consistent with those previously reported.
avail-effect-of-avastin-7.5mg-on-pfs.jpg